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This may lead to an inhibition of EGFR-mediated signal transduction and may inhibit cancer cell proliferation
Smiles: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N
including HER2/ERBB2
Williams GR
8(2):303-8
NNC 55-0396 - CAS# 357400-13-6 203580 Hydrochloride This may lead to anNNC 55 0396 is a T type calcium channel blocker. NNC 55 0396 inhibits angiogenesis via suppression of hypoxia inducible factor 1 signal transduction. NNC 55 0396 suppressed mitochondrial reactive oxygen species mediated HIF 1 expression as well as stabilization by inhibiting protein synthesis in a dose dependent manner. NNC 55 0396 inhibited tumor induced angiogenesis in vitro and in vivo by suppressing HIF 1 stability. NNC 55 0396 could be a
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