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5 μM and 0
InChi: InChI=1S/C15H22N2
PFI-2 has been shown to bind to SETD7 by ITC (Kd=18nM)
In cell-based assays
p300 and CBP are transcriptional co-activators that modulate DNA replication
BAY 87-2243 - Hypoxia-inducible Factor-1 (HIF-1) Inhibitor. CAS# 1227158-85-1 60069 5 μM and 0BAY 87 2243, CAS No. 1227158 85 1, is a highly potent and selective inhibitor of hypoxia induced gene activation, which has antitumor activities by inhibition of mitochondrial complex I. BAY 87 2243 mproves local tumor control after fractionated irradiation in a schedule dependent manner in head and neck human xenografts. BAY 87 2243 markedly decreased nuclear HIF 1 expression and pimonidazole hypoxic fraction already after 3 days of drug treatment.
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