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30)/t24-/m0/s1
Smiles: CCCC1=CC(=CC=N1)C(N)=S
InChi: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11
and also carries the US NCI designation NSC-707389
2013 Jun 7
PND-1186 Catalog No.:M9572-2 30)/t24-/m0/s1PND 1186, also known as SR 2156 and VS 4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1. 5 nM in vitro. PND 1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1. 0 M PND 1186 (>5 fold above IC50) had limited effects on cell proliferation. However, under non adherent conditions as spheroids and as colonies in soft agar, 0. 1 M PND 1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase 3
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