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C24hr and t1/2 of 3643 ng/ml (9%)
InChi: InChI=1S/C24H28ClN3O
Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH)
2 substrates of this enzyme
(S)-Hydroxychloroquine ((S)-HCQ) is the enantiomer of Hydroxychloroquine
Amikacin hydrate ingolimod hydrochloride C24hr and t1/2 of 3643Amikacin hydrate (BAY 41 6551 hydrate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against most Gram negative bacteria including gentamicin and tobramycin resistant strains. Amikacin hydrate also inhibits the infections caused by susceptible Nocardia and