AZ-3 60246 Treatment of AML cell lines

Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability

Chemical Name: (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide

CAS Number: 601514-19-6

InChiKey: OJMOGUKIYRAILM-UHFFFAOYSA-N

Chemical Name: N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(E)-2-{4-methoxy-1H-pyrrolo[2

AZ-3 60246 Treatment of AML cell linesAZ 3 is a potent and selective JAK1 inhibitor with an IC50 of 34 nM. Product information CAS Number: 2228908 91 4 Molecular Weight: 385. 48 Formula: C20H28FN7 Chemical Name: N4 [(2R) butan 2 yl] N2 {2 fluoro 5 [(1S, 4S) 5 methyl 2, 5 diazabicyclo[2. 2. 1]heptan 2 yl]pyridin 3 yl} 5 methylpyrimidine 2, 4 diamine Smiles: CN1C[C@@H]2C[C@H]1CN2C1=CN=C(F)C(=C1)NC1=NC(N[C@H](C)CC)=C(C)C=N1 InChiKey: UPSHDXGMMFOWPL KBMXLJTQSA N InChi: InChI=1S C20H28FN7 c1 5