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GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages
InChi: InChI=1S/C17H23NO3
InChiKey: XXUXXCZCUGIGPP-WLRTZDKTSA-N
InChiKey: XLLJFSCSXTYVTN-UHFFFAOYSA-N
2'-bioxolan]-5-yl]-1
ACP-5862 4420 GW3965 dose-dependently regulates lps-mediated liverACP 5862 is a major active, circulating, pyrrolidine ring opened metabolite of Acalabrutinib with an IC50 of 5. 0 nM for Bruton tyrosine kinase (BTK). ACP5862 is a weak timedependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM. Product information CAS Number: 2230757 47 6 Molecular Weight: 481. 51 Formula: C26H23N7O3 Chemical Name: 4 {8
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